666IGMA - Brain Transplant (ft. Skeiz and LankFrampard)

666IGMA - Echo Chamber (ft. LankFrampard & Silence Kills)

666IGMA - Live New Breaks [May 2017]

Trappist-1 Released!

Where can you find Trappist-1? Spotify, iTunes, Apple Music, Google Play, Amazon, Pandora, Deezer, Tidal, YouTube, Microsoft Groove, ClaroMusica, Saavn, MediaNet, SoundCloud and more! I'm a nice guy, so I'll tell you that Google Play is selling this album for $5.99 while some places, like Amazon want to charge more. I do not know why! I tried to make every track and the entire album as cheap as humanly possible! 

What if you want a physical version, in a nice DVD case, shrink-wrapped, and pressed, not burned? Then click here. The retail price is $3.00 + shipping. If you'd like to get it even cheaper and happen to live locally to me (in the Saint Petersburg, Clearwater or Tampa area), I have some special copies and will sign them and link you up with other awesome goodies for about $5. Can't beat that! Just E-Mail me and let me know! Here is all the artwork associated with this release, including image of what the DVD case looks like.

Here is the track list:

1. Umbrella Corporation [3:37]
2. Lose Weight [3:13]
3. Mountain Top [3:13]
4. Tommy Gun [3:08]
5. Vampiric Evolution [3:22]
6. That's How I'm Moving It [3:16]
7. Exodus (feat. Mario the Kidd) [3:39]
8. Killed for Less [2:48]
9. Grave Robber [3:28]
10. Gieger [4:11]
11. Dead or Alive [3:04]
12. Eons [3:13]
13. Laugh Face [3:45]
14. Sharp Cheddar [3:27]
15. Soul Eater [3:35]
16. Against the Gravel [5:00]
17. Trap Hau5 Five [3:35]

N-Methylphenethylamine (NMPEA), positional isomer of amphetamine, found in nature and also endogenous? A plant containing it may also contain DMT and Methamphetamine (and be growing in your back yard).

Wikipedia for NMPEA:

"PEA and NMPEA are both alkaloids that are found in a number of different plant species as well.[5] Some Acacia species, such as A. rigidula, contain remarkably high levels of NMPEA (~2300–5300 ppm).[6] NMPEA is also present at low concentrations (< 10 ppm) in a wide range of foodstuffs.[7]"

That was one of the primary parts that caught my eye. What is the effects of this substance? It may not be too active orally...

NMPEA is a pressor, with 1/350 x the potency of epinephrine.[17]

As with PEA, NMPEA is metabolized relatively rapidly by monoamine oxidases during first pass metabolism;[3][18] both compounds are preferentially metabolized by MAO-B.[3][18]

If it is vaporized or injected, what are the effects like? Euphoria? Stimulation? Obviously there are things that could be combined with it, orally, to inhibit the process that breaks it down...

N-Metyl-Phenylethylamine's half-life is very short. .It is metabolized by MAO-A, MAO-B, aldehyde dehydrogenase and dopamine-beta-hydroxylase. If you like to get long effect take an MAO inhibitor (MAOI) like Phenalzine

When the initial phenylethylamine brain concentration is low, brain levels can be increased 1000-fold when taking an MAO inhibitor (MAOI) and by 3times when the initial concentration is high.

Phenethylamine, similar to amphetamine in its action, releases norepinephrine and dopamine.

Amphetamine

NMPEA

                                                   

What else may be combined with it to make it stronger, make the effects more pronounced, or to maybe even alter it slightly into something more viable for recreational purposes?

It is listed in some places as aiding fat burning, meaning it may be available in some dietary supplements, which would not be surprising.

Then, here is the real gem I found researching this so far (and a commentary by Shulgin!)

In 1997[1] and 1998,[2] researchers at Texas A&M University reported finding amphetamine and methamphetamine in the foliage of two Acacia species native to Texas, A. berlandieri and A. rigidula. Previously, both of these compounds had been thought to be human inventions.[3] Like methylphenidate (Ritalin), amphetamines also prevent the monoamine transporters for dopamine and norepinephrine from recycling them (called reuptake inhibition), which leads to increased amounts of dopamine and norepinephrine in synaptic clefts.

Now remember, A. Rigidula is the plant mentioned way up above this that contains NMPEA. What else does it contain?

Amines and Alkaloids:

phenethylamine N,N-dimethylphenethylamine N,N-dimethyl-"-methylphenethylamine p-hydroxyamphetamine tyramine 3-5-dimethoxytyramine 3,4-dimethoxy-5-hydroxy-$-phenethylamine hordenine N,N-dimethyldopamine tryptamine N,N-dimethyltryptamine N-methylmescaline nicotine anhalamine peyophorine nortryptyline 3-"-cumyl-1,3,4-oxadiazolidine-2,5-dione p-hydroxypipecolamide 4-methyl-2-pyridinamine

N-methylphenethylamine amphetamine methamphetamine p-methoxyamphetamine N-methyltyramine candicine dopamine N-methyldopamine 3-methoxytyramine N-methyltryptamine mescaline trichocereine nornicotine anahalidine mimosine (methyl ester) musk ambrette pipecolamide 1,4-benzezediamine

Phytoestrogens:

octylphenol \ aristolone (Z)-9-octadecenoic acid (Z,Z,Z)-9,12,15-octadecatrienoic acid 3b-acetoxy-17-methyl-5a-18-abeoandrost-13-ene

nonylphenol 3b-cholest-5-en-3-ol (Z,Z)-9,12,-octadecanoic acid

4-Methoxyamphetamine

If you read this properly... then this plant contains methamphetamine, as well as DMT... It also contains 4-Methoxyamphetamine (A schedule I substance, DMT is also Schedule I).

The real kicker though is that Amphetamine and Methamphetamine were thought to be MAN MADE substances, not found in nature. Here is a full commentary by Shulgin in a Question/Answer format:

Question: Are you familiar with Acacia berlandieri and A. rigidula which were noted to contain various a-methyl-b-phenethylamines? Do you have any ideas as to what the botanical origins of these structural carbon skeletons might be? The literature citations are PHYTOCHEM. (1998), 49(5), 1377 and PHYTOCHEM. (1997), 46(2), 249.

Answer: I am familiar with the literature concerning these two West Texas Acacia species, but not with the plants themselves. I had both these PHYTOCHEMISTRY papers in my Acacia file but I must admit that I have some very mixed feelings about them.

What caught my curiosity immediately was the casual indifference shown to what is certainly an extraordinary discovery. Here, amongst some 40 or so alkaloids found in each of these two species, there were five amphetamines that had heretofore been thought to be inventions of man. Two of these are Schedule II drugs, Amphetamine and Methamphetamine. Two are Schedule I drugs, N,N-Dimethylamphetamine and 4-Methoxyamphetamine. And the fifth one is a major human metabolite of Amphetamine, 4-Hydroxyamphetamine. To my knowledge, none of these had ever before been reported as being natural plant alkaloids. This unprecedented discovery elicited only a passing line of comment in the earlier of the two papers.

My first thoughts as to origin were directed towards the well known natural hydroxylated amphetamines such as norephedrine, ephedrine and N-methylephedrine. I know that ephedrine and pseudoephedrine, frequent precursors in the illegal synthesis of methamphetamine, can be reduced to methamphetamine as an artifact of analysis. The sample insertion conditions of the gas chromatograph can effect this conversion. But then, there was no mention of any of these hydroxylated alkaloids as being present in either Acacia.

Might a contaminated round-bottomed flask have been purchased at a garage sale outside an abandoned meth-lab and served as the source of these "man-made" compounds? Unlikely, even in Texas.

Even more dramatic, one of these amphetamines, the 4-Methoxyamphetamine, is the increasingly notorious PMA that is appearing as one of the lethal "Ecstasy" offerings in the rave scene.

Several months ago I tried to contact, individually, the two principal authors, by both e-mail and personal snail-mail, and I have received no response as yet.

There is certainly precedent for a drug which was originally man-made, to be discovered in a plant. N,N-Dimethyltryptamine (DMT) was first synthesized by Manske, in Canada, in the 1930s. It was over twenty years later that it was discovered in a plant from South America. But such an event usually evokes considerable commentary. Here it seems that an exciting story is being ignored. Am I missing something?

-- Dr. Shulgin

Yes, what is he missing? If this is true, this is a rather ground-breaking discovery. Is it well known that methamphetamine and emphetamine, along with DMT and all these other substances are found within this singe plant?

N,N,-Dimethyltryptamine

Granted some of the data may be incorrect, but I'd like to first find a source debunking or attempting to debunk this data before I would go that far.

Mescaline

What are the concentrations of these substances in this plant? I know the DMT can't be too high of a concentration, as I've never heard of this plant being used as a source for DMT the way Mimosa Hostilis and a few others are used. If the concentration was high, it was be involved in popular teks...

Wikipedia comments:

A phytochemical study of V. rigidula[6] by workers at the Texas A & M University Agricultural Research and Extension Center at Uvalde, TX, reported the presence of over forty alkaloids, including low amounts (up to ~ 15 ppm) of several amphetamines that had previously been found by the same research group in the related species Senegalia berlandieri,[7] but which otherwise are known only as products of laboratory synthesis. Compounds found in the highest concentrations (ranging from a few hundred to a few thousand ppm) were phenylethylamine, N-methylphenethylamine, tyramine and N-methyltyramine. Other notable compounds reported were N,N-dimethyltryptamine, mescaline, amphetamine, methamphetamine and nicotine, although these were found in low concentrations (e.g. mescaline at 3-28 ppm).

The presence of such an unprecedented chemical range of psychoactive compounds, including ones not previously found in nature, in a single plant species has led to the suggestion that some of these findings may have resulted from cross-contamination or were possibly artifacts of the analytical technique.[8]

Why has this not been further tested, in all of these years?

Where are the A. rigidula teks?

Finally... secure

Yes! I have finally been able to secure everything and offer encrypted protection via SSL through my server. This process took me longer than I'd like to admit and should be fairly easy and straight-forward on most server environments. There are also ways, as I found out, to be able to do this for free, instead of having to pay some kind of certificate issuer or signing authority. 

While there exist ways to "self sign" certificates for a server, I still chose to use a third party to complete the process. If you also run a server, I recommend researching into letsencrypt, which assuming you have the proper Virtual Hosts set up with your HTTPD, like Apache2, then with a couple of configuration files and then a few CLI entries, you can be on your way to fully utilizing https:// - I've even gone an extra step and *forced* all connections to my server that attempt to use http:// to convert to https://.

Now I can finish working on some of the fun projects I had going before for some companies and even plan to launch a browser-based game soon. I have actually had it in development for a while in various incarnations, but will reveal more details about it in the near future. One of the recent stumbling blocks I had recently was enabling SSL... that and I tried to originally program the game to fully utilize AJAX techniques. I've limited their usage now, as they were crippling the development.

Server maintenance

While I attempt to enable SSL, there may be some errors with pages loading and a few other things on www.666igma.com - this process should be completed within the next few hours, so just be patient.